2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-14566S1
    Donepezil-d5 1128086-25-8 ≥99.0%
    Donepezil-d5 is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively.
    Donepezil-d5
  • HY-B0196AR
    Venlafaxine hydrochloride (Standard) 99300-78-4 99.99%
    Venlafaxine (hydrochloride) (Standard) is the analytical standard of Venlafaxine (hydrochloride). This product is intended for research and analytical applications. Venlafaxine hydrochloride (Wy 45030 hydrochloride) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant.
    Venlafaxine hydrochloride (Standard)
  • HY-B0407AS
    Chlorpromazine-d6 hydrochloride 1228182-46-4 99.88%
    Chlorpromazine-d6 (hydrochloride) is the deuterium labeled Chlorpromazine. Chlorpromazine is an inhibitor of dopamine receptor, 5-HT receptor, potassium channel, sodium channel.
    Chlorpromazine-d6 hydrochloride
  • HY-B0649S1
    Propofol-d18 1189467-93-3
    Propofol-d18 is the deuterium labeled Propofol. Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission.
    Propofol-d18
  • HY-B1184S1
    Mephenytoin-d5 1185032-66-9 98.72%
    Mephenytoin-d5 is the deuterium labeled Mephenytoin. Mephenytoin, an anticonvulsant, is the CYP2C19 and CYP2B6 substrate.
    Mephenytoin-d5
  • HY-N0138S1
    Theobromine-d3 65566-69-0 99.78%
    Theobromine-d3 is the deuterium labeled Theobromine. Theobromine is a methylxanthine found in cacao beans which can inhibit adenosine receptor A1 (AR1) signaling.
    Theobromine-d3
  • HY-P10936A
    AQP4 (201-220) TFA 98.01%
    AQP4 (201-220) TFA is an encephalitogenic epitope of AQP-4. AQP4 (201-220) TFA can induce experimental autoimmune encephalomyelitis (EAE) (characterized by midline lesions in the brain, retinal pathology, and lesions at the grey matter/white matter border zone in the spinal cord). AQP-4 is a target antigen in neuromyelitis optica.
    AQP4 (201-220) TFA
  • HY-W001601
    Budipine 57982-78-2 99.41%
    Budipine is an anti-parkinson agent. Budipine also is a substrate of P-glycoprotein (P-gp), is mediated the uptake into the brain by P-gp. Budipine also is N-methyl-d-aspartate (NMDA) antagonist, and has indirect dopaminergic effects through an improved dopamine release, the inhibition of monoamine oxidase type B (MAO-B). Budipine can be used for the research of CNS disorders include Parkinson disease.
    Budipine
  • HY-W002899
    (S)-Boc-nipecotic acid 88495-54-9 ≥98.0%
    (S)-Boc-nipecotic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    (S)-Boc-nipecotic acid
  • HY-W007828
    Methyl 3-phenylpropanoate 103-25-3 ≥98.0%
    Methyl 3-phenylpropanoate is a phenylpropionate compound. Methyl 3-phenylpropanoate derivatives interfere with insect feeding behavior. Methyl 3-phenylpropanoate can be used to study insect feeding behavior.
    Methyl 3-phenylpropanoate
  • HY-W009009
    L-838417 286456-42-6 99.22%
    L-838417 is a selective partial agonist at the α2, α3 and α5 subtypes of the GABAA receptor and an antagonist at the α1, with binding Ki values of 0.79 nM, 0.67 nM, 1.67 nM, 267 nM, 2.25 nM and 2183 nM for α1β3γ2, α2β3γ2, α3β3γ2, α4β3γ2, α5β3γ2 and α6β3γ2.
    L-838417
  • HY-W012618
    1-Phenyl-1-propanol 93-54-9 ≥98.0%
    1-Phenyl-1-propanol is used as a chiral building block and synthetic intermediate in the pharmaceutical industries. 1-Phenyl-1-propanol is an intermediate of anti-depressant agent Fluoxetine (HY-B0102).
    1-Phenyl-1-propanol
  • HY-W019710
    (E,E)-RGFP966 1396841-57-8 99.31%
    (E,E)-RGFP966 is a selective and CNS permeable HDAC3 inhibitor that can be used for the research of Huntington’s disease.
    (E,E)-RGFP966
  • HY-W039116
    Thalidomide-4-Br 2093536-12-8
    Thalidomide-4-Br (compound 53) is a compound with a bromodomain. Thalidomide-4-Br can be used in the research of inflammation, tumor and neurology.
    Thalidomide-4-Br
  • HY-W050162
    (E)-3,4,5-Trimethoxycinnamic acid 20329-98-0 99.95%
    (E)-3,4,5-Trimethoxycinnamic acid (TMCA) is a cinnamic acid substituted by multi-methoxy groups. (E)-3,4,5-Trimethoxycinnamic acid is an orally active and potent GABAA/BZ receptor agonist. (E)-3,4,5-Trimethoxycinnamic exhibits favourable binding affinity to 5-HT2C and 5-HT1A receptor, with IC50 values of 2.5 and 7.6 μM, respectively. (E)-3,4,5-Trimethoxycinnamic acid shows anticonvulsant and sedative activity. (E)-3,4,5-Trimethoxycinnamic acid can be used for the research of insomnia, headache and epilepsy.
    (E)-3,4,5-Trimethoxycinnamic acid
  • HY-W069604
    Thalidomide-5-Br 26166-92-7
    Thalidomide-5-Br (compound 4) is a compound with a bromodomain. Thalidomide-5-Br can be used in the research of inflammation, tumor and neurology.
    Thalidomide-5-Br
  • HY-W077226
    AChE-IN-23 6297-14-9 99.49%
    AChE-IN-23 (compound 3h) is an acetylcholinesterase (AChE) inhibitor with an IC50 value of 48.3 μM.
    AChE-IN-23
  • HY-W105694
    3-Aminopropylphosphonic acid 13138-33-5 ≥98.0%
    3-Aminopropylphosphonic acid ((3-Aminopropyl)phosphonic acid) is a phosphonic acid analogue of GABA and a GABAB receptor agonist.
    3-Aminopropylphosphonic acid
  • HY-W338140
    Methionine sulfoximine 1982-67-8 ≥98.0%
    Methionine sulfoximine (2-Amino-4-(S-methylsulfonimidoyl)butanoic acid) is an irreversible inhibitor of glutamine synthetase with convulsive effects. Methionine sulfoximine is able to affect the metabolism of glutamate and glutamine, which may provide important insights in neurobiological research. Methionine sulfoximine has also been used to study mechanisms related to epilepsy and its inhibitory potential.
    Methionine sulfoximine
  • HY-W718300
    Indole-3-pyruvic acid-d5 85163-57-1
    Indole-3-pyruvic acid-d5 is deuterated labeled Indole-3-pyruvic acid. Indole-3-pyruvic acid, a keto analogue of tryptophan, is an orally active AHR agonist. Indole-3-pyruvic acid has antioxidant properties, and can be used in the research of inflammation, anxiety.
    Indole-3-pyruvic acid-d5
Cat. No. Product Name / Synonyms Application Reactivity